Bitter melon (Momordica charantia) is a vine originally from India and other Asian countries. It has been traditionally used to treat diabetes.

Bitter melon contains a chemical that acts like insulin to help reduce blood sugar levels.

People commonly use bitter melon for diabetes, osteoarthritis, athletic performance, and many other conditions, but there is no good scientific evidence to support these uses.

Bitter melon is sometimes called bitter gourd. Don’t confuse this with Ivy gourd, which is a different plant.

There is interest in using bitter melon for a number of purposes, but there isn’t enough reliable information to say whether it might be helpful.

When taken by mouth: Bitter melon is possibly safe when used for up to 4 months. Bitter melon might cause upset stomach in some people. There isn’t enough reliable information to know if bitter melon is safe to use long-term.

When applied to the skin: There isn’t enough reliable information to know if bitter melon is safe. It might cause a rash.

Special precautions & warnings:

Pregnancy: Bitter melon is possibly unsafe when taken by mouth during pregnancy. Certain chemicals in bitter melon might harm the pregnancy.

Breast-feeding: There isn’t enough reliable information to know if bitter melon is safe to use when breast-feeding. Stay on the safe side and avoid use.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Bitter melon seeds might cause severe anemia in people who have G6PD deficiency. Until more is known, avoid bitter melon seeds if you have G6PD deficiency.

Surgery: Bitter melon might interfere with blood sugar control during and after surgery. Stop using bitter melon at least 2 weeks before a scheduled surgery.

Moderate

Be cautious with this combination.

Medications for diabetes (Antidiabetes drugs)

Bitter melon might lower blood sugar levels. Taking bitter melon along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Medications moved by pumps in cells (P-Glycoprotein Substrates)

Some medications are moved in and out of cells by pumps. Bitter melon might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.

Herbs and supplements that might lower blood sugar

Bitter melon might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, cassia cinnamon, chromium, and prickly pear cactus.

There are no known interactions with foods.

Bitter melon has most often been used by adults in doses of 0.5-12 grams by mouth daily for up to 16 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.

African Cucumber, Ampalaya, Balsam Pear, Balsam-Apple, Balsambirne, Balsamine, Balsamo, Bitter Apple, Bitter Cucumber, Bitter Gourd, Bittergurke, Carilla Fruit, Carilla Gourd, Cerasee, Chinli-Chih, Concombre Africain, Courge Amère, Cundeamor, Fructus Mormordicae Grosvenori, Karavella, Karela, Kareli, Kathilla, Kerala, Korolla, Kugua, Kuguazi, K’u-Kua, Lai Margose, Margose, Melón Amargo, Melon Amer, Momordica, Momordica charantia, Momordica murcata, Momordique, Paroka, Pepino Montero, Poire Balsamique, Pomme de Merveille, P’u-T’ao, Sorosi, Sushavi, Ucche, Vegetable insulin, Wild Cucumber.

To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.

1. Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. View abstract.
2. Yook JS, Kwak JJ, Jeong WM, et al. Possible adaptogenic effects of Momordica charantia on high-intensity training-induced alteration in the hypothalamic-pituitary-adrenal axis. J Clin Biochem Nutr. 2020;67:290-6. View abstract.
3. Kwak JJ, Yook JS, Ha MS. Potential biomarkers of peripheral and central fatigue in high-intensity trained athletes at high-temperature: a pilot study with Momordica charantia (bitter melon). J Immunol Res. 2020;2020:4768390. View abstract.
4. Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21:672-7. doi: 10.1089/jmf.2017.0114. View abstract.
5. Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. View abstract.
6. Soo May L, Sanip Z, Ahmed Shokri A, Abdul Kadir A, Md Lazin MR. The effects of Momordica charantia (bitter melon) supplementation in patients with primary knee osteoarthritis: A single-blinded, randomized controlled trial. Complement Ther Clin Pract. 2018;32:181-6. doi: 10.1016/j.ctcp.2018.06.012. View abstract.
7. Yue J, Sun Y, Xu J, et al. Cucurbitane triterpenoids from the fruit of Momordica charantia L. and their anti-hepatic fibrosis and anti-hepatoma activities. Phytochemistry. 2019;157:21-7. doi: 10.1016/j.phytochem.2018.10.009. View abstract.
8. Wen JJ, Gao H, Hu JL, et al. Polysaccharides from fermented Momordica charantia ameliorate obesity in high-fat induced obese rats. Food Funct. 2019;10:448-57. doi: 10.1039/c8fo01609g. View abstract.
9. Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143:379-87. View abstract.
10. Boone CH, Stout JR, Gordon JA, et al. Acute effects of a beverage containing bitter melon extract (CARELA) on postprandial glycemia among prediabetic adults. Nutr Diabetes. 2017;7:e241. View abstract.
11. Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. View abstract.
12. Somasagara RR, Deep G, Shrotriya S, Patel M, Agarwal C, Agarwal R. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells. Int J Oncol. 2015;46:1849-57. View abstract.
13. Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. View abstract.
14. Bhattacharya S, Muhammad N, Steele R, Peng G, Ray RB. Immunomodulatory role of bitter melon extract in inhibition of head and neck squamous cell carcinoma growth. Oncotarget. 2016;7:33202-9. View abstract.
15. Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145. View abstract.
16. Dutta PK, Chakravarty AK, CHowdhury US, and Pakrashi SC. Vicine, a favism-inducing toxin from Momordica charantia Linn. seeds. Indian J Chem 1981;20B(August):669-671.
17. Srivastava Y. Antidiabetic and adaptogenic properties of Momordica charantia extract:An experimental and clinical evaluation. Phytother Res 1993;7:285-289.
18. Raman A and Lau C. Anti-diabetic properties and phytochemistry of Momordica charantia L. (Cucurbitaceae). Phytomedicine 1996;2:349-362.
19. Stepka W, Wilson KE, and Madge GE. Antifertility investigation on Momordica. Lloydia 1974;37:645.
20. Baldwa VS, Bhandara CM, Pangaria A, and et al. Clinical trials in patients with diabetes mellitus of an insulin-like compound obtained from plant source. Upsala J Med Sci 1977;82:39-41.
21. Takemoto, D. J., Dunford, C., and McMurray, M. M. The cytotoxic and cytostatic effects of the bitter melon (Momordica charantia) on human lymphocytes. Toxicon 1982;20:593-599. View abstract.
22. Dixit, V. P., Khanna, P., and Bhargava, S. K. Effects of Momordica charantia L. fruit extract on the testicular function of dog. Planta Med 1978;34:280-286. View abstract.
23. Aguwa, C. N. and Mittal, G. C. Abortifacient effects of the roots of Momordica angustisepala. J Ethnopharmacol. 1983;7:169-173. View abstract.
24. Akhtar, M. S. Trial of Momordica charantia Linn (Karela) powder in patients with maturity-onset diabetes. J Pak.Med Assoc 1982;32:106-107. View abstract.
25. Welihinda, J., Arvidson, G., Gylfe, E., Hellman, B., and Karlsson, E. The insulin-releasing activity of the tropical plant momordica charantia. Acta Biol Med Ger 1982;41:1229-1240. View abstract.
26. Chan, W. Y., Tam, P. P., and Yeung, H. W. The termination of early pregnancy in the mouse by beta-momorcharin. Contraception 1984;29:91-100. View abstract.
27. Takemoto, D. J., Jilka, C., and Kresie, R. Purification and characterization of a cytostatic factor from the bitter melon Momordica charantia. Prep.Biochem 1982;12:355-375. View abstract.
28. Wong, C. M., Yeung, H. W., and Ng, T. B. Screening of Trichosanthes kirilowii, Momordica charantia and Cucurbita maxima (family Cucurbitaceae) for compounds with antilipolytic activity. J Ethnopharmacol. 1985;13:313-321. View abstract.
29. Ng, T. B., Wong, C. M., Li, W. W., and Yeung, H. W. Isolation and characterization of a galactose binding lectin with insulinomimetic activities. From the seeds of the bitter gourd Momordica charantia (Family Cucurbitaceae). Int J Peptide Protein Res 1986;28:163-172. View abstract.
30. Ng, T. B., Wong, C. M., Li, W. W., and Yeung, H. W. Insulin-like molecules in Momordica charantia seeds. J Ethnopharmacol. 1986;15:107-117. View abstract.
31. Liu, H. L., Wan, X., Huang, X. F., and Kong, L. Y. Biotransformation of sinapic acid catalyzed by Momordica charantia peroxidase. J Agric Food Chem 2-7-2007;55:1003-1008. View abstract.
32. Yasui, Y., Hosokawa, M., Kohno, H., Tanaka, T., and Miyashita, K. Troglitazone and 9cis,11trans,13trans-conjugated linolenic acid: comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer cell lines. Chemotherapy 2006;52:220-225. View abstract.
33. Nerurkar, P. V., Lee, Y. K., Linden, E. H., Lim, S., Pearson, L., Frank, J., and Nerurkar, V. R. Lipid lowering effects of Momordica charantia (Bitter Melon) in HIV-1-protease inhibitor-treated human hepatoma cells, HepG2. Br J Pharmacol 2006;148:1156-1164. View abstract.
34. Shekelle, P. G., Hardy, M., Morton, S. C., Coulter, I., Venuturupalli, S., Favreau, J., and Hilton, L. K. Are Ayurvedic herbs for diabetes effective? J Fam.Pract. 2005;54:876-886. View abstract.
35. Nerurkar, P. V., Pearson, L., Efird, J. T., Adeli, K., Theriault, A. G., and Nerurkar, V. R. Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells. J Nutr 2005;135:702-706. View abstract.
36. Senanayake, G. V., Maruyama, M., Sakono, M., Fukuda, N., Morishita, T., Yukizaki, C., Kawano, M., and Ohta, H. The effects of bitter melon (Momordica charantia) extracts on serum and liver lipid parameters in hamsters fed cholesterol-free and cholesterol-enriched diets. J Nutr Sci Vitaminol.(Tokyo) 2004;50:253-257. View abstract.
37. Kohno, H., Yasui, Y., Suzuki, R., Hosokawa, M., Miyashita, K., and Tanaka, T. Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition. Int J Cancer 7-20-2004;110:896-901. View abstract.
38. Senanayake, G. V., Maruyama, M., Shibuya, K., Sakono, M., Fukuda, N., Morishita, T., Yukizaki, C., Kawano, M., and Ohta, H. The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats. J Ethnopharmacol 2004;91(2-3):257-262. View abstract.
39. Pongnikorn, S., Fongmoon, D., Kasinrerk, W., and Limtrakul, P. N. Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy. J Med Assoc Thai. 2003;86:61-68. View abstract.
40. Rebultan, S. P. Bitter melon therapy: an experimental treatment of HIV infection. AIDS Asia 1995;2:6-7. View abstract.
41. Lee-Huang, S., Huang, P. L., Sun, Y., Chen, H. C., Kung, H. F., Huang, P. L., and Murphy, W. J. Inhibition of MDA-MB-231 human breast tumor xenografts and HER2 expression by anti-tumor agents GAP31 and MAP30. Anticancer Res 2000;20(2A):653-659. View abstract.
42. Wang, Y. X., Jacob, J., Wingfield, P. T., Palmer, I., Stahl, S. J., Kaufman, J. D., Huang, P. L., Huang, P. L., Lee-Huang, S., and Torchia, D. A. Anti-HIV and anti-tumor protein MAP30, a 30 kDa single-strand type-I RIP, shares similar secondary structure and beta-sheet topology with the A chain of ricin, a type-II RIP. Protein Sci. 2000;9:138-144. View abstract.
43. Wang, Y. X., Neamati, N., Jacob, J., Palmer, I., Stahl, S. J., Kaufman, J. D., Huang, P. L., Huang, P. L., Winslow, H. E., Pommier, Y., Wingfield, P. T., Lee-Huang, S., Bax, A., and Torchia, D. A. Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions. Cell 11-12-1999;99:433-442. View abstract.
44. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. View abstract.
45. Dans AM, Villarruz MV, Jimeno CA, et al. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J Clin Epidemiol 2007;60:554-9. View abstract.
46. Shibib BA, Khan LA, Rahman R. Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem J 1993;292:267-70. View abstract.
47. Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3. View abstract.
48. Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. View abstract.
49. Anila L, Vijayalakshmi NR. Beneficial effects of flavonoids from Sesamum indicum, Emblica officinalis and Momordica charantia. Phytother Res 2000;14:592-5. View abstract.
50. Grover JK, Vats V, Rathi SS, Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J Ethnopharmacol 2001;76:233-8. View abstract.
51. Vikrant V, Grover JK, Tandon N, et al. Treatment with extracts of Momordica charantia and Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats. J Ethnopharmacol 2001;76:139-43. View abstract.
52. Lee-Huang S, Huang PL, Nara PL, et al. MAP 30: a new inhibitor of HIV-1 infection and replication. FEBS Lett 1990;272:12-8. View abstract.
53. Lee-Huang S, Huang PL, Huang PL, et al. Inhibition of the integrase of human immunodeficiency virus (HIV) type