Belladonna (Atropa belladonna) is a plant that grows from Western Europe to the Himalayas. It’s also grown in the US. All parts of the plant are poisonous.

Belladonna has chemicals that can alter the function of the body’s nervous system and cause changes to saliva, sweat, pupil size, urination, digestive functions, and others. Belladonna can also cause increased heart rate and blood pressure.

Despite known safety concerns, people use belladonna for asthma, the common cold, hemorrhoids, Parkinson disease, and many other conditions, but there is no good scientific evidence to support these uses.

Since 2010, the FDA has issued several warnings about homeopathic teething tablets and gels for infants that contain belladonna. Serious side effects including seizures, breathing problems, and agitation have been reported in infants taking these products, and some have died.

There is interest in using belladonna for a number of purposes, but there isn’t enough reliable information to say whether it might be helpful.

When taken by mouth: Belladonna is likely unsafe. It contains chemicals that can be poisonous even at low doses. Serious side effects might include blurred vision, fever, fast heartbeat, inability to urinate or sweat, hallucinations, spasms, mental problems, convulsions, coma, and others.

When applied to the skin: Belladonna is possibly unsafe. There isn’t enough reliable information available to know if the poisonous chemicals in belladonna can be absorbed through the skin.

When given as a suppository (rectally): Belladonna is possibly unsafe. There isn’t enough reliable information available to know if the poisonous chemicals in belladonna can be absorbed from the rectum.

Special precautions & warnings:

Pregnancy: Belladonna is likely unsafe when taken by mouth during pregnancy. It contains potentially toxic chemicals and has been linked to reports of serious side effects.

Breast-feeding: Belladonna is likely unsafe when taken by mouth while breast-feeding. It can reduce milk production and also passes into breast milk.

Children: Belladonna is likely unsafe when taken by mouth. Consuming as few as 2 berries can be fatal in small children. Also, severe side effects and death have occurred in infants treated with homeopathic teething products containing belladonna.

Heart disease: Belladonna might cause rapid heartbeat and might make some heart conditions worse.

Down syndrome: People with Down syndrome might be extra-sensitive to the chemicals in belladonna and their harmful effects.

Gastrointestinal (GI) conditions: Belladonna might slow down the stomach and intestines, which could make some GI conditions worse.

Narrow-angle glaucoma: Belladonna might make narrow-angle glaucoma worse.

Moderate

Be cautious with this combination.

Cisapride (Propulsid)

Belladonna contains atropine. Atropine can reduce the effects of cisapride. Taking belladonna with cisapride might reduce the effects of cisapride.

Drying medications (Anticholinergic drugs)

Belladonna can block a chemical in the body called acetylcholine, which has many important functions. Some medications, called anticholinergic drugs, also block acetylcholine. There is some concern that taking them together might increase the risk for confusion, blurred vision, increased sweating, and increased heart rate.

There are no known interactions with herbs and supplements.

There are no known interactions with foods.

Despite known safety concerns, belladonna is found in some herbal supplements and homeopathic products. The FDA has issued several warnings about homeopathic teething tablets and gels for infants that contain belladonna. Taking belladonna is unsafe and can cause serious side effects.

Atropa belladonna, Atropa acuminata, Baccifère, Belladona, Belladone, Belle-Dame, Belle-Galante, Bouton Noir, Cerise du Diable, Cerise Enragée, Cerise d’Espagne, Deadly Nightshade, Devil’s Cherries, Devil’s Herb, Divale, Dwale, Dwayberry, Grande Morelle, Great Morel, Guigne de la Côte, Herbe à la Mort, Herbe du Diable, Indian Belladonna, Morelle Furieuse, Naughty Man’s Cherries, Poison Black Cherries, Suchi.

To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.

1. Package insert: belladonna and opium suppositories. Perrigo, Minneapolis, MN. Revised May 2019. (Accessed from https://dailymed.nlm.nih.gov, January 21, 2022).
2. Package insert: belladonna alkaloids with phenobarbital tablets. West-ward Pharmaceutical Corp., Eatontown, NJ. Revised April 2005. (Accessed from https://dailymed.nlm.nih.gov, January 21, 2022).
3. Chen L, Yeung JC, Anderson DR. Anisocoria secondary to anticholinergic mydriasis from homeopathic pink eye relief drops. Clin Med Res. 2017;15(3-4):93-5. View abstract.
4. Huff ML, Fikse D, Surmaitis RM, Greenberg MR. Acute angle closure glaucoma precipitated by homeopathic eyedrops containing Atropa belladonna. Am J Emerg Med. 2021 Nov 3:S0735-675700902-5. View abstract.
5. Abbasi J. Amid Reports of Infant Deaths, FTC Cracks Down on Homeopathy While FDA Investigates. JAMA. 2017;317:793-795. View abstract.
6. Berdai MA, Labib S, Chetouani K, Harandou M. Atropa belladonna intoxication: a case report. Pan Afr Med J 2012;11:72. View abstract.
7. Lee MR. Solanaceae IV: Atropa belladonna, deadly nightshade. J R Coll Physicians Edinb 2007;37:77-84. View abstract.
8. Certain Homeopathic Teething Products: FDA Warning- Confirmed Elevated Levels of Belladonna. FDA Safety Alerts for Human Medical Products, January 27, 2017. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm538687.htm. [Accessed March 22, 2016]
9. Golwalla A. Multiple extrasystoles: an unusual manifestation of belladonna poisoning. Dis Chest 1965;48:83-84.
10. Hamilton M and Sclare AB. Belladonna poisoning. Br Med J 1947;611-612.
11. Cummins BM, Obetz SW, Wilson MR, and et al. Belladonna poisoning as a facet of psychodelia. Jama 1968;204:153.
12. Sims SR. Poisoning due to belladonna plasters. Br Med J 1954;1531.
13. Firth D and Bentley JR. Belladonna poisoning from eating rabbit. Lancet 1921;2:901.
14. Bergmans M, Merkus J, Corbey R, and et al. Effect of Bellergal Retard on climacteric complaints: a double-blind, placebo-controlled study. Maturitas 1987;9:227-234.
15. Lichstein, J. and Mayer, J. D. Drug therapy in the unstable bowel (irritable colon). A 15-month double-blind clinical study in 75 cases of response to a prolonged-acting belladonna alkaloid-phenobarbital mixture or placebo. J.Chron.Dis. 1959;9:394-404.
16. Steele CH. The use of Bellergal in the prophylactic treatment of some types of headaches. Ann Allergy 1954;42-46.
17. Whitmarsh, T. E., Coleston-Shields, D. M., and Steiner, T. J. Double-blind randomized placebo-controlled study of homoeopathic prophylaxis of migraine. Cephalalgia 1997;17:600-604. View abstract.
18. Friese KH, Kruse S, Ludtke R, and et al. The homoeopathic treatment of otitis media in children–comparisons with conventional therapy. Int J Clin Pharmacol Ther 1997;35:296-301. View abstract.
19. Ceha LJ, Presperin C, Young E, and et al. Anticholinergic toxicity from nightshade berry poisoning responsive to physostigmine. The Journal of Emergency Medicine 1997;15:65-69. View abstract.
20. Schneider, F., Lutun, P., Kintz, P., Astruc, D., Flesch, F., and Tempe, J. D. Plasma and urine concentrations of atropine after the ingestion of cooked deadly nightshade berries. J Toxicol Clin Toxicol 1996;34:113-117. View abstract.
21. Trabattoni G, Visintini D, Terzano GM, and et al. Accidental poisoning with deadly nightshade berries: a case report. Human Toxicol. 1984;3:513-516. View abstract.
22. Eichner ER, Gunsolus JM, and Powers JF. “Belladonna” poisoning confused with botulism. Jama 8-28-1967;201:695-696. View abstract.
23. Goldsmith SR, Frank I, and Ungerleider JT. Poisoning from ingestion of a stramonium-belladonna mixture: flower power gone sour. J.A.M.A 4-8-1968;204:169-170. View abstract.
24. Gabel MC. Purposeful ingestion of belladonna for hallucinatory effects. J.Pediatr. 1968;72:864-866. View abstract.
25. Lance, J. W., Curran, D. A., and Anthony, M. Investigations into the mechanism and treatment of chronic headache. Med.J.Aust. 11-27-1965;2:909-914. View abstract.
26. Dobrescu DI. Propranolol in the treatment of disturbances of the autonomic nervous system. Curr.Ther.Res Clin Exp 1971;13:69-73. View abstract.
27. King, J. C. Anisotropine methylbromide for relief of gastrointestinal spasm: double- blind crossover comparison study with belladonna alkaloids and phenobarbital. Curr.Ther Res Clin.Exp 1966;8:535-541. View abstract.
28. Shader RI and Greenblatt DJ. Uses and toxicity of belladonna alkaloids and synthetic anticholinergics. Seminars in Psychiatry 1971;3:449-476. View abstract.
29. Rhodes, J. B., Abrams, J. H., and Manning, R. T. Controlled clinical trial of sedative-anticholinergic drugs in patients with the irritable bowel syndrome. J.Clin.Pharmacol. 1978;18:340-345. View abstract.
30. Robinson, K., Huntington, K. M., and Wallace, M. G. Treatment of the premenstrual syndrome. Br.J.Obstet.Gynaecol. 1977;84:784-788. View abstract.
31. Stieg, R. L. Double-blind study of belladonna-ergotamine-phenobarbital for interval treatment of recurrent throbbing headache. Headache 1977;17:120-124. View abstract.
32. Ritchie, J. A. and Truelove, S. C. Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide, and ispaghula husk. Br Med J 2-10-1979;1:376-378. View abstract.
33. Williams HC and du Vivier A. Belladonna plaster–not as bella as it seems. Contact Dermatitis 1990;23:119-120. View abstract.
34. Kahn A., Rebuffat E, Sottiaux M, and et al. Prevention of airway obstructions during sleep in infants with breath- holding spells by means of oral belladonna: a prospective double-blind crossover evaluation. Sleep 1991;14:432-438. View abstract.
35. Davidov, M. I. [Factors predisposing to acute urine retention in patients with prostatic adenoma]. Urologiia. 2007;:25-31. View abstract.
36. Tsiskarishvili, N. V. and Tsiskarishvili, TsI. [Colorimetric determination of eccrine sudoriferous glands functional condition in case of hyperhidrosis and their correction by belladonna]. Georgian.Med News 2006;:47-50. View abstract.
37. Bettermann, H., Cysarz, D., Portsteffen, A., and Kummell, H. C. Bimodal dose-dependent effect on autonomic, cardiac control after oral administration of Atropa belladonna. Auton.Neurosci. 7-20-2001;90(1-2):132-137. View abstract.
38. Walach, H., Koster, H., Hennig, T., and Haag, G. The effects of homeopathic belladonna 30CH in healthy volunteers — a randomized, double-blind experiment. J.Psychosom.Res. 2001;50:155-160. View abstract.
39. Heindl, S., Binder, C., Desel, H., Matthies, U., Lojewski, I., Bandelow, B., Kahl, G. F., and Chemnitius, J. M. [Etiology of initially unexplained confusion of excitability in deadly nightshade poisoning with suicidal intent. Symptoms, differential diagnosis, toxicology and physostigmine therapy of anticholinergic syndrome]. Dtsch Med Wochenschr 11-10-2000;125:1361-1365. View abstract.
40. Southgate, H. J., Egerton, M., and Dauncey, E. A. Lessons to be learned: a case study approach. Unseasonal severe poisoning of two adults by deadly nightside (Atropa belladonna). Journal of the Royal Society of Health 2000;120:127-130. View abstract.
41. Balzarini, A., Felisi, E., Martini, A., and De Conno, F. Efficacy of homeopathic treatment of skin reactions during radiotherapy for breast cancer: a randomised, double-blind clinical trial. Br Homeopath J 2000;89:8-12. View abstract.
42. Corazziari, E., Bontempo, I., and Anzini, F. Effects of cisapride on distal esophageal motility in humans. Dig Dis Sci 1989;34:1600-1605. View abstract.
43. Hyland’s Teething Tablets: Recall – Risk of Harm to Children. FDA News Release, October 23, 2010. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm230764.htm (Accessed 26 October 2010).
44. Alster TS, West TB. Effect of topical vitamin C on postoperative carbon dioxide laser resurfacing erythema. Dermatol Surg 1998;24:331-4. View abstract.
45. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98. View abstract.
46. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
47. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
48. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
49. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
50. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.

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