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Background

  • Like peas and beans, red clover belongs to the family of plants called legumes. Red clover contains substances called isoflavones—compounds that are structurally related/similar to estrogen. Red clover supplements have been promoted for menopause symptoms and osteoporosis.
  • Historically, red clover was used for asthma, whooping cough, cancer, and gout. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis.

How Much Do We Know?

  • Red clover has been studied in people, but the research hasn’t shown clear benefits for any health condition.

What Have We Learned?

  • Studies on the effects of red clover on menopause symptoms such as hot flashes and on blood levels of cholesterol and other lipids have had inconsistent results.
  • Only a small amount of research has been done on the effects of red clover on bone density in menopausal women, and the results have been inconsistent.

What Do We Know About Safety?

  • Red clover extracts have been used in clinical studies for as long as 3 years with apparent safety.
  • Women should not take red clover supplements during pregnancy or while breastfeeding.

Keep in Mind

  • Take charge of your health—talk with your health care providers about any complementary health approaches you use. Together, you can make shared, well-informed decisions.

For More Information

NCCIH Clearinghouse

The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners.

Toll-free in the U.S.: 1-888-644-6226

Telecommunications relay service (TRS): 7-1-1

Website: https://www.nccih.nih.gov

Email: info@nccih.nih.gov (link sends email)

PubMed®

A service of the National Library of Medicine, PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed.

Website: https://pubmed.ncbi.nlm.nih.gov/

Office of Dietary Supplements (ODS), National Institutes of Health (NIH)

ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements).

Website: https://ods.od.nih.gov

Email: ods@nih.gov (link sends email)

Key References

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