What is it?
Despite serious safety concerns, pennyroyal is used for the common cold, pneumonia, fatigue, ending a pregnancy (abortion), and as an insect repellant, but there is no good scientific evidence to support these uses.
In manufacturing, pennyroyal oil is used as a dog and cat flea repellent, and as a fragrance for detergents, perfumes, and soaps.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for PENNYROYAL are as follows:
Insufficient evidence to rate effectiveness for…
- Ending a pregnancy (abortion).
- Canker sores.
- Common cold.
- Indigestion (dyspepsia).
- Fatigue.
- Gas (flatulence).
- Gallbladder disease.
- Gout.
- Insect repellant.
- Liver disease.
- Mosquito repellant.
- Pain.
- Pneumonia.
- Stomach pain.
- Other conditions.
More evidence is needed to rate the effectiveness of pennyroyal for these uses.
Is it safe?
When applied to the skin: Pennyroyal oil is LIKELY UNSAFE when applied to the skin.
Special precautions & warnings:
Pennyroyal is LIKELY UNSAFE for anyone to use, but it is especially unsafe for people with the following conditions.
Pregnancy and breast-feeding: It is LIKELY UNSAFE to take pennyroyal by mouth or apply it to your skin when pregnant or breast-feeding. There is some evidence that pennyroyal oil can cause abortions by causing the uterus to contract. But the dose needed in order to cause an abortion could kill the mother or cause life-long kidney and liver damage.
Children: It is LIKELY UNSAFE to give children pennyroyal by mouth. Infants have developed serious liver and nervous system injuries, or even death, after taking pennyroyal.
Kidney disease: The oil in pennyroyal can damage the kidney and make existing kidney disease worse.
Liver disease: The oil in pennyroyal can cause liver damage and might make existing liver disease worse.
Are there interactions with medications?
- Acetaminophen (Tylenol, others)
- Pennyroyal can cause liver damage. Taking pennyroyal with acetaminophen, which can also cause liver damage, might increase the risk for liver damage.
Are there interactions with herbs and supplements?
- Iron
- Pennyroyal might reduce the absorption of iron from supplements.
Are there interactions with foods?
- Iron-containing foods
- Pennyroyal might reduce the absorption of iron from foods.
How is it typically used?
Other names
Methodology
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.
References
- Farid O, Zeggwagh NA, Ouadi FE, Eddouks M. Mentha pulegium aqueous extract exhibits antidiabetic and hepatoprotective effects in streptozotocin-induced diabetic rats. Endocr Metab Immune Disord Drug Targets 2019;19:292-301. doi: 10.2174/1871530318666181005102247. View abstract.
- Fozard J, Hieger M. Hepatic failure from pennyroyal tea interaction with medications metabolized by the cytochrome P450 enzymes. Am J Ther 2019 Aug 13. doi: 10.1097/MJT.0000000000001052. [Epub ahead of print]. View abstract.
- Vaghardoost R, Ghavami Y, Sobouti B. The effect of Mentha pulegium on healing of burn wound injuries in rat. World J Plast Surg 2019;8:43-50. doi: 10.29252/wjps.8.1.43. View abstract.
- Hurrell RF, Reddy M, Cook JD. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. Br.J Nutr 1999;81:289-295. View abstract.
- Sullivan JB Jr, Rumack BH, Thomas H Jr, et al. Pennyroyal oil poisoning and hepatotoxicity. JAMA 1979;242:2873-4. View abstract.
- Anderson IB, Mullen WH, Meeker JE, et al. Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature. Ann Intern Med 1996;124:726-34. View abstract.
- Sudekum M, Poppenga RH, Raju N, Braselton WE Jr. Pennyroyal oil toxicosis in a dog. J Am Vet Med Assoc 1992;200:817-8.. View abstract.
- Bakerink JA, Gospe SM Jr, Dimand RJ, Eldridge MW. Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants. Pediatrics 1996;98:944-7. View abstract.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association’s Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Foster S, Tyler VE. Tyler’s Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
02/13/2020