What is it?
Eleuthero is often considered an adaptogen. Adaptogens are a class of substances that are believed to stimulate the body’s resistance to physical, environmental, and emotional stressors. Eleuthero contains many chemicals that affect the brain, immune system, and certain hormones.
People use eleuthero for genital herpes, diabetes, athletic performance, memory and thinking skills, the common cold, and many other conditions, but there is no good scientific evidence to support most of these uses.
Don’t confuse eleuthero with other herbs called “ginseng,” including American Ginseng, Blue Cohosh, Canaigre, Codonopsis, Panax Ginseng, and Panax Notoginseng. These are not the same.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for ELEUTHERO are as follows:
Possibly effective for…
- Genital herpes. Taking a specific eleuthero extract (Elagen) by mouth might help reduce genital herpes outbreaks.
There is interest in using eleuthero for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.
Is it safe?
Special precautions & warnings:
Pregnancy and breast-feeding: There isn’t enough reliable information to know if eleuthero is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Children: Eleuthero is possibly safe in teenagers (ages 12-17 years) when taken by mouth for up to 6 weeks. There isn’t enough reliable information to know if it is safe to use long-term or in young children.
Heart conditions: Eleuthero might cause a pounding heart, irregular heartbeat, or high blood pressure in people who have heart disorders. If you have a heart condition, only use eleuthero under the supervision of a healthcare provider.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Eleuthero might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t use eleuthero.
Are there interactions with medications?
- Digoxin (Lanoxin)
- There is some concern that eleuthero might increase levels of digoxin. This could increase the effects and side effects of digoxin. If you are taking digoxin, speak with a healthcare provider before taking eleuthero.
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
- Some medications are changed and broken down by the liver. Eleuthero might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
- Some medications are changed and broken down by the liver. Eleuthero might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications for diabetes (Antidiabetes drugs)
- Eleuthero might lower blood sugar levels. Taking eleuthero along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
- Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates)
- Some medications are moved in and out of cells by pumps. Eleuthero might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
- Medications moved by pumps in cells (P-glycoprotein substrates)
- Some medications are moved in and out of cells by pumps. Eleuthero might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
- Medications that decrease the immune system (Immunosuppressants)
- Eleuthero can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking eleuthero along with these medications might decrease the effects of these medications.
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
- Eleuthero might slow blood clotting. Taking eleuthero along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
- Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
- Some medications are changed and broken down by the liver. Eleuthero might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
- Some medications are changed and broken down by the liver. Eleuthero might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Are there interactions with herbs and supplements?
- Herbs and supplements that might lower blood sugar
- Eleuthero might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
- Herbs and supplements that might slow blood clotting
- Eleuthero might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
Are there interactions with foods?
- There are no known interactions with foods.
How is it typically used?
Other names
Methodology
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.
References
- Narimanyan M, Jamalyan K, Balyan A, et al. Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study. J Tradit Complement Med 2021;11:552-562. View abstract.
- Oh E, Kim Y, Park SY, et al. The fruit of Acanthopanax senticosus Harms improves arterial stiffness and blood pressure: a randomized, placebo-controlled trial. Nutr Res Pract. 2020;14:322-333. View abstract.
- Tohda C, Matsui M, Inada Y, et al. Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults. Nutrients. 2020 Jan 23;12. pii: E303. View abstract.
- U.S. Food and Drug Administration. Detention Without Physical Examination of Foods Labeled As Being Or Containing Siberian Ginseng. Washington, DC: U.S. Food and Drug Administration. September 15, 2015. https://www.accessdata.fda.gov/cms_ia/importalert_143.html. Accessed December 2019.
- Barth A, Hovhannisyan A, Jamalyan K, Narimanyan M. Antitussive effect of a fixed combination of Justicia adhatoda, Echinacea purpurea and Eleutherococcus senticosus extracts in patients with acute upper respiratory tract infection: A comparative, randomized, double-blind, placebo-controlled study. Phytomedicine. 2015;22:1195-200. doi: 10.1016/j.phymed.2015.10.001. View abstract.
- Schaffler K, Wolf OT, Burkart M. No benefit adding Eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study. Pharmacopsychiatry. 2013 Jul;46:181-90.
- Freye E, GLeske J. Siberian ginseng results in beneficial effects on glucose metabolism in diabetes type 2 patients: a double blind placebo-controlled study in comparison to panax ginseng. Int J Clin Nutr. 2013;1:11-17.
- Bang JS, Chung YH, et al. Clinical effect of a polysaccharide-rich extract of Acanthopanax senticosus on alcohol hangover. Pharmazie. 2015 Apr;70:269-73.
- Rasmussen, P. Phytotherapy in an influenza pandemic. Australian Journal of Medical Herbalism 2009;21:32-37.
- Li Fang, Li Wei, Fu HongWei, Zhang QingBo, and Koike, K. Pancreatic lipase-inhibiting triterpenoid saponins from fruits of Acanthopanax senticosus. Chem Pharm Bull (Tokyo) 2007;55:1087-1089.
- Yarnell E and Abascal K. Holistic approaches to prostate cancer. Altern Complement Ther 2008;14:164-180.
- Castleman, M. 6 TOP HERBAL TONICS. Mother Earth News 2008;228:121-127.
- Yao, L, Kim KyoungSook, Kang NamYoung, Lee YoungChoon, Chung EunSook, Cui Zheng, Kim CheorlHo, Han XiangFu, Kim JungIn, Yun YeongAe, and Lee JaiHeon. Inhibitory effect of a traditional Chinese formulation, Hyul-Tong-Ryung, on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells. Journal of Traditional Medicines Sugitani: Medical and Pharmaceutical Society for Wakan-Yaku 2011;26:25-34.
- Rhéaume, K. Adapting to stress. Alive: Canada’s Natural Health & Wellness Magazine 2007;298:56-57.
- Daley, J. Adaptogens. J Complement Med 2009;8:36-38.
- Shohael, A. M, Hahn, E. J, and Paek, K. Y. Somatic embryogenesis and secondary metabolite production through bioreactor culture of Siberian ginseng (Eleutherococcus senticosus). Acta Horticulturae 2007;764:181-185.
- Baczek, K. Accumulation of biologically active compounds in Eleuthero (Eleutherococcus senticosus/Rupr. et Maxim./Maxim.) grown in Poland. Herba Polonica 2009;55:7-13.
- Zauski, D, Smolarz, H. D, and Chomicki, A. TLC screening for eleutherosides B, E, and E1, and isofraxidin in the roots of six Eleutherococcus species cultivated in Poland. Acta Chromatographica 2010;22:581-589.
- Oh SY, Aryal DK, Kim Y-G, and Kim H-G. Effects of R. glutinosa and E. senticosus on postmenopausal osteoporosis. Korean J Physiol Pharmacol 2007;11:121-127.
- Yim, S, Jeong JuCheol, and Jeong JiHoon. Effect of an extract of Acanthopanax senticosus on restoration of hair loss in mouse. Chung-Ang Journal of Medicine Seoul: Institute of Medical Science, Chung-Ang University College of Medicine 2007;32:81-84.
- Chen, C. Y. O, Ribaya-Mercado, J. D, McKay, D. L, Croom, E, and Blumberg, J. B. Differential antioxidant and quinone reductase inducing activity of American, Asian, and Siberian ginseng. Food Chemistry 2010;119:445-451.
- Weng S, Tang J, Wang G, Wang X, and Wang H. Comparison of the addition of Siberian ginseng (Acanthopanax senticosus) versus fluoxetine to lithium for the treatment of bipolar disorder in adolescents: a randomized, double-blind trial. Curr Ther Res 2007;68:280-290.
- Williams M. Immunoprotection against herpes simplex type II infection by eleutherococcus root extract. J Alt Comp Med 1995;13:9-12.
- Wu, Y. N. X. Q. Wang Y. F. Zhao J. Z. Wang H. J. Chen and H. Z. Effect of Ciwujia (Radix acanthopanacis senticosus) preparation on human stamina. J.Hyg.Res. 1996;25:57-61.
- McNaughton, L. G. Egan and G. Caelli. A comparison of Chinese and Russian ginseng as ergogenic aids to improve various facets of physical fitness. Int.Clin.Nutr.Rev. 1989;9:32-35.
- Plowman, S. A. K. Dustman H. Walicek C. Corless and G. Ehlers. The effects of ENDUROX on the physiological responses to stair-stepping exercise. Res.Q.Exerc.Sport. 1999;70:385-388.
- Baczek, K. Accumulation of biologically active compounds in Eleuthero (Eleutherococcus senticosus/Rupr. et Maxim./Maxim.) grown in Poland. Herba Polonica Poznan´: Instytut Ro?lin i Przetworów Zielarskich 2009;55:7-13.
- Zhou, YC, Yi ChuanZhu, and Hu YiXiu. Experimental study on the antiradiation and antifatigue effects of soft capsule made of cistanche and acanthopanax senticosus and jujube. China Tropical Medicine Hainan: Editorial Department of China Tropical Medicine 2008;8:35-37.
- Lim JungDae and Choung MyoungGun. Screening of biological activities of Acanthopanax senticosus fruits extracts. Korean J Crop Sci 2011;56:1-7.
- Lin ChiaChin, Hsieh ShuJon, Hsu ShihLan, and Chang, C. M. J. Hot pressurized water extraction of syringin from Acanthopanax senticosus and in vitro activation on rat-blood macrophages. Biochem Eng J 2007;37:117-124.
- Lauková, A, Plachá, I, Chrastinová, L, Simonová, M, Szabóová, R, Strompfová, V, Jur?ík, R, and Porá?ová, J. Effect of Eleutherococcus senticosus extract on the phagocytic activity in rabbits. Slovenský Veterinársky ?asopisKošice: Institute for Postgraduate Education of Veterinary Surgeons 2008;33:251-252.
- Won, K. M, Kim, P. K, Lee, S. H, and Park, S. I. Effect of the residuum extract of Siberian ginseng Eleutherococcus senticosus on non-specific immunity in olive flounder Paralichthys olivaceus. Fisheries Science 2008;74:635-641.
- Kong XiangFeng, Yin YuLong, Wu GuoYao, Liu HeJun, Yin FuGui, Li TieJun, Huang RuiLin, Ruan Zheng, Xiong Hua, Deng ZeYuan, Xie MingYong, Liao YiPing, and Kim SungWoo. Dietary supplementation with Acanthopanax senticosus extract modulates cellular and humoral immunity in weaned piglets. Asian-Australasian Journal of Animal Sciences Kyunggi-do: Asian-Australasian Association of Animal Production Societies 2011;20:1453-1461.
- Sohn, S. H, Jang, I. S, Moon, Y. S., Kim, Y. J, Lee, S. H, Ko, Y. H, Kang, S. Y, and Kang, H. K. Effect of dietary Siberian ginseng and Eucommia on broiler performance, serum biochemical profiles and telomere length. Korean Journal of Poultry Science 2008;35:283-290.
- Zhang, Y. Advances in the clinical application of Aidi Injection. Chinese Journal of Information on Traditional Chinese Medicine Beijing: Chinese Journal of Information on Traditional Chinese Medicine 2007;14:91-93.
- Engel, K. herbal tonics. Natural Health 2007;38:91-94.
- Wilson, L. Review of adaptogenic mechanisms: Eleuthrococcus senticosus, Panax ginseng, Rhodiola rosea, Schisandra chinensis and Withania somnifera. Australian Journal of Medical Herbalism 2007;19:126-131.
- Khalsa, Karta Purkh Singh. Build your immunity. Better Nutrition 2009;71:20-21.
- Zhang Yi. Advances in the clinical application of Aidi Injection. Chinese Journal of Information on Traditional Chinese Medicine Beijing: Chinese Journal of Information on Traditional Chinese Medicine 2007;14:91-93.
- Zauski, D and Smolarz, H. D. Eleutherococcus senticosus – an exemplary adaptogenic plant. Postepy Fitoterapii Warszawa: Borgis Wydawnictwo Medyczne 2008;9:240-246.
- Azizov, A. P. [Effects of eleutherococcus, elton, leuzea, and leveton on the blood coagulation system during training in athletes]. Eksp Klin Farmakol 1997;60:58-60. View abstract.
- Tong, L., Huang, T. Y., and Li, J. L. [Effects of plant polysaccharides on cell proliferation and cell membrane contents of sialic acid, phospholipid and cholesterol in S 180 and K 562 cells]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1994;14:482-484. View abstract.
- Ben Hur, E. and Fulder, S. Effect of Panax ginseng saponins and Eleutherococcus senticosus on survival of cultured mammalian cells after ionizing radiation. Am.J Chin Med 1981;9:48-56. View abstract.
- Tseitlin, G. I. and Saltanov, A. I. [Indices of antistress activity of an Eleutherococcus extracts in lymphogranulomatosis after splenectomy]. Pediatriia. 1981;:25-27.